by Allegra Via

Protein-protein interfaces and 3D modelling of protein complexes

## Learning Objectives

Protein protein interfaces

  • Learners can tell the difference between stable and transient interactions and can make at least one example for each type of interaction Learners can describe the main features of protein-protein interfaces
  • Learners can give the definition of “hot spots”

3D modelling of protein complexes

  • Learners can tell the difference between bound and unbound docking
  • Learners are able to explain the three key ingredients of docking and how they are interconnected
  • Learners can explain why clustering docking solutions can be helpful
  • Learners can use ClusPro to generate 3D models a protein-protein complex
  • Learners can critically analyse ClusPro results

Complex prediction:

Structures and models:

Bibliography: